WORLD / Health
HIV infection raises lung cancer risk - Study
(Reuters)
Updated: 2007-07-09 11:09
NEW YORK - Independent of cigarette smoking, infection with HIV, the
virus that causes AIDS, is associated with an elevated risk for
developing lung cancer, a study shows.
Dr. Gregory D. Kirk from the Bloomberg School of Public Health, Johns
Hopkins University, Baltimore, Maryland and colleagues evaluated lung
cancer deaths among participants in injection drug users followed since
1998 as part of an AIDS study.
There were 27 lung cancer deaths among the 2,086 participants; 14 of the
deaths occurred in HIV-infected subjects.
After adjusting for potentially confounding factors like age, sex and
smoking status, HIV infection was associated with a 3.6-fold increased
risk for lung cancer death compared to HIV-negative status.
"As HIV-infected persons survive longer, we are continuing to see that
non-AIDS outcomes are becoming the primary causes of morbidity and
mortality," Kirk told Reuters Health. "Our study suggests that the risks
for these non-AIDS outcomes may be modulated by HIV infection."
"We hope to combine our data with other HIV and at-risk cohort studies to
confirm the association between HIV and lung cancer," Kirk said.
"Also, we are evaluating a series of smoking/tobacco related biomarkers
in HIV infected and uninfected persons with similar smoking patterns to
compare if the biological effect of smoking differs by HIV status, and if
so, is this related to degree of immune suppression or to antiretroviral
treatment," he added.
SOURCE: Clinical Infectious Diseases, July 1, 2007.
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